Posted by hyperfocus on June 23, 2011, at 20:05:13
In reply to Re: BDNF in depression and fibromyalgia » hyperfocus, posted by SLS on June 23, 2011, at 18:23:19
The interesting thing is I've found that the effect of amitrip on my day-to-day functioning is best when in the range 150-225mg. Anything higher makes me feel much, much worse. I can't even take drugs like metformin and glimiperide that affect the liver metabolism of amitrip. Tianeptine has also gotten a lot of praise for it's neurotrophic properties but I find tianeptine not to have any significant improvement on my overall day-to-day condition and can actually make me feel a whole lot worse under certain conditions. Apathy is a major negative side-effect for me on tianeptine yet I cannot deny it's immediate next-day memory-boosting effects. Fish oil, flaxseed oil or anything with significant Omega-3 also seems to exert this pronounced negative day-to-day negative effect on me.
I've always suspected that while these drugs and supplements exert their effects on neurogenesis and neuroplasticity, they can actually make our day-to-day symptoms considerably worse. Do you thing this is possible - drugs that do actually repair brain structures but also make us feel much worse? Maybe we should look towards always taking these neurotrophic drugs and trying to combat their adverse effects on our symptoms some other way?
C-PTSD: social phobia, major depression, dissociation
Currently on 150mg amitriptyline single dose at night.
Improving.
poster:hyperfocus
thread:989086
URL: http://www.dr-bob.org/babble/20110619/msgs/989243.html