Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Valproate + Tiagabine combination

Posted by Stephen32 on May 21, 2011, at 14:15:30

I want to come off of my 4mg Klonopin daily which I have been taking for around six months because of severe anxiety. Tolerance has kicked in and sleep is getting worse.

In the past Depakote ER was pretty useful for a relatively fast and smooth benzodiazepine withdrawal. As I don't want to take benzos again after the W/D I thought maybe the combination of valproate (Depakote ER) & tiagabine (Gabitril) might be a good long-term strategy for treatment resistant social / generalized anxiety. I also had some mood swing problems in the past.

As valproate and tiagabine increase brain GABA levels by different mechanisms of action there should be a synergistic or at least additive effect IMHO. The safety of the combination has been tested in patients with epilepsy receiving up to 30-50 mg/day (much more than necessary for anxiety disorders) - http://www.ncbi.nlm.nih.gov/pubmed/15693805

What do you think about the idea?



Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:Stephen32 thread:985874
URL: http://www.dr-bob.org/babble/20110515/msgs/985874.html