Posted by SLS on January 22, 2011, at 20:30:38
In reply to Re: New antidepressant just approved. Vilazodone, posted by Conundrum on January 22, 2011, at 14:08:12
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> Pharmacologically, it looks unimpressive. Why would you want 5 HT1A partial agonism if you have serotonin acting as a full agonist. Isn't that the way serotonerigic drugs are though to work, by activating and downregulating that receptor? The only advantage I can see, from a pharmacological standpoint, is that the partial agonist might work more like an antagonist, and keep serotonin output higher than on a normal SSRI.Signal-to-noise ratio.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.
poster:SLS
thread:977653
URL: http://www.dr-bob.org/babble/20110115/msgs/977717.html