Posted by hopefullynow on October 11, 2010, at 13:38:51
In reply to Re: Advice please re. clomipramine/anafranil » hopefullynow, posted by kizzie2 on October 11, 2010, at 12:23:28
yes, decreasing noradrenergic and dopaminergic activity leads to apathy, lack of enthusiasm, drive, energy or libido.Serotonergic TCA's seems to be kinder than SSRI's in this area, but over time they appear to lead to this kind of state of numbing.Best approach would be to add to clomipramine (which hopefully abolish depresion on you)some NA/DA agent like nortryptiline, wellbutrin, desipramine...Dopamine agonists doesn't seem to do something solid on the long run.If they work, they pop up in a short time.
For me, clomipramine at 50mg/day had/have a robust response and continous efficacity in treating depression but left me somehow numb.Adding Maprotiline (NA TCA), the numbing/amotivational state was reversed.Hope it helps,
regards
> Hi - thank you for reply. Apologies for my ignorance but when you say 'decreases noradrenergic and dopaminergic activity ' - does that mean that anafranil/clomipramine can actually increase symptoms of depression (loss of enthusiasm/motivation) over time?
>
> This definately seems to be the case with me and have wondered if it could be down to the medication.
>
> Thanks
>
> Kizzie
poster:hopefullynow
thread:949082
URL: http://www.dr-bob.org/babble/20101009/msgs/965380.html