Posted by Brainbeard on October 3, 2010, at 8:27:53
In reply to Re: Clomipramine's Tail Is Smashing My Little Future, posted by Brot on October 3, 2010, at 7:53:43
> Fluvoxamine is a strong enzyme inhibitor (CYP1A2). you shouldnt take it with clomipramine.... if I recall correctly.
Brot, you're my man. You're absolutely right.
But this is precisely why my p-doc put me on this combination. fLUVOXamine, by strongly inhibiting 1A2, inhibits clomipramine's metabolism, which results in lower levels of the noradrenergic metabolite and higher levels of clomipramine itself (the mother drug), clomipramine being a potent SRI and therefore probably most important for treating OCD. So it's a matter of tweaking, really.
The fact that this p-doc knew all about this favourable interaction made me know for sure he was the right doc for the job.
Current meds: clomipramine 225mg, fluvoxamine (Luvox) 50mg, amitriptyline 10mg, bethanechol 25-50mg.
PRN: oxazepam 5-10mg
poster:Brainbeard
thread:964485
URL: http://www.dr-bob.org/babble/20100926/msgs/964563.html