Posted by Conundrum on September 10, 2010, at 15:18:51
In reply to Re: nortripytline + MAOi? anti histamine interraction, posted by linkadge on September 10, 2010, at 10:28:34
> Mice lacking both the NET transporter and MAO-B have greatly increased cardiac NE levels and blood pressure. Dopamine in the prefrontal cortex isn't the be all too. Some studies show that there is hypermetabolism in the prefrontal cortex in certain depressive states. In ketamine responders, for instance, there is a dramatic *decrease* in prefrontal metabolism. I think there are studies showing the same in SSRI responses.
>Nortriptyline doesn't block all transporters and MAO inhibitors can actually be used to lower blood pressure. They actually end up decreasing blood pressure I believe this works through something called octapine or something. So there is a difference between MAO B depleted h rats on paper and MAO inhibitors in vivo.
Iatrogenic post-SSRI problems: anhedonia, memory and concentration problems, sexual dysfunction. (not a formal DX)
Country:USA
Currently taking Lamictal, mirtazapine, and abilify.
poster:Conundrum
thread:961847
URL: http://www.dr-bob.org/babble/20100908/msgs/961963.html