Posted by Conundrum on September 10, 2010, at 6:41:48
In reply to Re: Another semi failed trial » Conundrum, posted by SLS on September 10, 2010, at 5:03:58
"Moreover, aripiprazole, 0.3 mg/kg, slightly but significantly increased dopamine release in the medial PREFRONTAL CORTEX but not in the NUCLEUS ACCUMBENS.(Nac) These increases were significantly inhibited by WAY100635. By contrast, aripiprazole, 3.0 mg/kg and 10 mg/kg, significantly decreased dopamine release in the nucleus accumbens but not the medical prefrontal cortex. "
It actually can decrease dopamine in the Nac.
"However, aripiprazole 10 mg/kg significantly decreased dopamine release in the both regions. Aripiprazole had no effect on acetylcholine release in the medial prefrontal cortex, hippocampus, or nucleus accumbens at any dose, except for 3.0 mg/kg, which decreased acetylcholine release in the nucleus accumbens only. "
Abilify is actually a 5 HT2C antagonist/agonist so that be part of the reason why there is no increase in the NAC.
http://www.ncbi.nlm.nih.gov/pubmed/16336943This seems to be the effect of the atypical drugs with 5HT2a antagonism and weak 5HT2C antagonism.
(may have to delete spaces in link for it to work)
Abilify is actually a 5 HT2C antagonist/agonist so that be part of the reason why there is no dopamine increase in the NAC.
http://www.ncbi.nlm.nih.gov/pubmed/16336943Zyprexa which is a stronger 5 HT2C antagonist the Nac.
http://www.springerlink.com/content/lmcjhp01pqf34jxy/
Here is a link to the binding affinities of Atypical Antipsychotics
http://www.nature.com/npp/journal/v28/n3/fig_tab/1300027t1.html#figure-title
Thats it before this gets moved to Neurotransmitters. :D
Iatrogenic post-SSRI problems: anhedonia, memory and concentration problems, sexual dysfunction. (not a formal DX)
Country:USA
Currently taking Lamictal, mirtazapine, and abilify.
poster:Conundrum
thread:961768
URL: http://www.dr-bob.org/babble/20100908/msgs/961897.html