Posted by desolationrower on June 19, 2010, at 17:15:46
i think i posted pre-results of this study or a similar one before.
Here, they used chronic dosing of paracetamol. Probably want to take a small amount of NAC with it if you go that way.
THere were some NSAID studies on depression before, but i mostly thought the inflammation was doing the work, but the second experiment supports a more direct effect.
Acetaminophen Reduces Social Pain: Behavioral and Neural Evidence.
Dewall CN, Macdonald G, Webster GD, Masten CL, Baumeister RF, Powell C, Combs D, Schurtz DR, Stillman TF, Tice DM, Eisenberger NI.
1University of Kentucky.
AbstractPain, whether caused by physical injury or social rejection, is an inevitable part of life. These two types of pain-physical and social-may rely on some of the same behavioral and neural mechanisms that register pain-related affect. To the extent that these pain processes overlap, acetaminophen, a physical pain suppressant that acts through central (rather than peripheral) neural mechanisms, may also reduce behavioral and neural responses to social rejection. In two experiments, participants took acetaminophen or placebo daily for 3 weeks. Doses of acetaminophen reduced reports of social pain on a daily basis (Experiment 1). We used functional magnetic resonance imaging to measure participants' brain activity (Experiment 2), and found that acetaminophen reduced neural responses to social rejection in brain regions previously associated with distress caused by social pain and the affective component of physical pain (dorsal anterior cingulate cortex, anterior insula). Thus, acetaminophen reduces behavioral and neural responses associated with the pain of social rejection, demonstrating substantial overlap between social and physical pain.
http://www.ncbi.nlm.nih.gov/pubmed/20548058-d/r
poster:desolationrower
thread:951509
URL: http://www.dr-bob.org/babble/20100615/msgs/951509.html