Posted by linkadge on May 25, 2010, at 20:25:13
In reply to Re: replicating ketamine depression effect, posted by bleauberry on May 25, 2010, at 17:49:41
Well, I am assuming both of us haven't tried many selective NMDA antagonists. Both zinc and magnesium have many secondary effects. Magnesium tends to lower BDNF while zinc does the opposite.
I don't find magnesium to be antidepressant but I do find low doses of zinc to be.
There is some target of ketamine which is very fast acting (i.e. virtually immediate). Zinc does have acute antidepressant effects in anmial models (unlike imipramine which takes weeks for the AD effect to be observed).
Linkadge
poster:linkadge
thread:948822
URL: http://www.dr-bob.org/babble/20100524/msgs/948887.html