Posted by Brainbeard on May 23, 2010, at 6:22:28
In reply to aide for deep stage sleep /sleep architecture?, posted by floatingbridge on May 14, 2010, at 1:29:09
Drugs that promote deep stage sleep are, to begin with, all 5HT2A-antagonists (as long as they don't have other properties that negate the effects of 5HT2A-antagonism on sleep). Amitriptyline is a moderately strong 5HT2A-antagonist, while its antihistaminergic sedation may help with falling asleep. Nortriptyline, amitriptyline's metabolite, is less strong but can still make a great difference for sleep. Its effects on noradrenaline may also be paradoxically sedating.
Geodon (ziprasidone) is a very potent 5HT2A-antagonist, while its effects on noradrenaline are highly sedating for many. I slept very deeply on 20-40mg of Geodon.
Risperdal is also a highly potent 5HT2A-antagonist, but it may have other properties that interfere with deep sleep. I experienced alternating sleeplessness and very deep sleep on low doses.
Pipamperone is a lesser known antipsychotic (brand name Dipiperone) that is also a fairly potent 5HT2A-antagonist.Neurontin (gabapentin) promotes deep stage sleep as well.
Current meds: 10mg melitracene + 0.5mg flupentixol; sertraline 100mg; amitriptyline 25mg; gabapentin (Neurontin) 300mg; melatonin 0.3mg. PRN: diazepam (Valium) 2.5-5mg.
poster:Brainbeard
thread:947403
URL: http://www.dr-bob.org/babble/20100514/msgs/948399.html