Posted by ed_uk2010 on April 24, 2010, at 19:38:37
In reply to Re: Multiple drug exposures and treatment resistence » SLS, posted by bulldog2 on April 24, 2010, at 17:42:59
>The body learns to recognize a foreign substance and how to break it down quickly and get rid of it.
Tolerance due to increased rate of metabolism only occurs with a minority of drugs eg. barbiturate sedatives - which induce the synthesis of drug metabolising enzymes in the liver. Tolerance to the majority of drugs (benzodiazepines, opioids, stimulants etc) is mainly due to cellular adaptations within the central nervous system.
Hope this info is useful.
poster:ed_uk2010
thread:944856
URL: http://www.dr-bob.org/babble/20100416/msgs/944924.html