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Re: Surprised at what I can eat on Parnate

Posted by inanimate peanut on January 2, 2010, at 20:16:57

In reply to Surprised at what I can eat on Parnate, posted by Maxime on January 1, 2010, at 13:55:56

I read an article that being on amitriptyline interfered with the pressor reaction of tyramine so that those on amitriptyline were less likely to have tyramine reactions. I assume it would be the same for nortriptyline, so my theory is that it's because you're on nortriptyline that you can get away with eating some cheeses, etc. The rest of us would be in trouble!

Here's the article just in case anyone was interested:
Lancet. 1982 Jul 24;2(8291):183-6.
Will amitriptyline prevent the "cheese" reaction of monoamine-oxidase inhibitors?
Pare CM, Kline N, Hallstrom C, Cooper TB.
Administration of amitriptyline greatly diminished the pressor response to intravenous tyramine in patients receiving monoamine-oxidase inhibitors (MAOIs). Dothiepin and trimipramine, however, produced little change in sensitivity to tyramine. It is suggested that a combination of amitriptyline and an MAOI, started together in a modest dose that is then increased, may protect patients against the potential dangers of eating tyramine-containing foods. However, because MAOIs allow a high proportion of ingested tyramine to be absorbed into the systemic circulation, patients treated with MAOIs, even in combination with amitriptyline, should not be encouraged to eat foods containing tyramine.


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poster:inanimate peanut thread:932001
URL: http://www.dr-bob.org/babble/20091227/msgs/932191.html