Posted by Elroy on December 31, 2009, at 16:31:59
In reply to LDN Low Dose Naltrexone Questions, posted by Bob on October 5, 2009, at 22:45:53
> I might be behind the curve here, but I recently came across some literature espousing Low Dose Naltrexone for, among other things, fibromyalgia symptoms. The prevailing recommendations suggest taking it some time between 10pm and 2am before going to bed. The theory is that it inhibits endogenous opiate receptors during the time of peak activity during sleep (I guess) thus raising the available levels of endorphins available. The usual doses for things like addiction problems is 50mg, but the LDN regimen calls for building up the dose by 1.5mg increments to a total of only 4.5mg.
>
> Anyway, I'm wondering if anyone here has any experience with LDN. I got the prescription for 1.5mg 3 times per day and took the first pill two nights ago. The next day I woke up refreshed and felt unusually calm and relaxed, yet energetic and focused. All my fibro type aches, pains and muscle problems seemed to evaporate and I was well enough to be able to clean and arrange a significant portion of the house. It was a day like I hadn't had in a long time. Last night I took another single 1.5mg pill and slept like a baby. Today I woke up and was irritated and tired. As the day progressed I felt somewhat weak, had some episodes of sweatiness, and had periods of depression. As good as the first day was, it has all seemed to have evaporated.
>
> Is LDN something that can build over time, or is this second day a bad sign, and an indicator that this is not a good thing to pursue? I am confounded by the good first day and how quicky it seemed to disappear.
>
> Bob
>
LDN is not really designed as a primary anti-depression or anti-anxiety agents... though many of its users HAVE reported very positive results in both of those categories as they apply to their individual cases.For some great informational sites and info see the following:
http://www.lowdosenaltrexone.org/http://www.lowdosenaltrexone.org/index.htm
http://www.lowdosenaltrexone.org/index.htm#What_is_low_dose_naltrexone
http://www.lowdosenaltrexone.org/ldn_and_ms.htm
http://www.lowdosenaltrexone.org/ldn_and_ai.htmhttp://en.wikipedia.org/wiki/Low_dose_naltrexone
http://www.lowdosenaltrexone.org/gazorpa/LDNFAQ.html
http://www.emaxhealth.com/1035/39/29168/more-magic-bullet-low-dose-naltrexone.html
http://www.ldnresearchtrustfiles.co.uk/docs/2009.pdf
(A 47-page Booklet of 47 Case Studies of the use of LDN... the booklet, once downloaded, can be printed out))https://ldndatabase.dabbledb.com/page/cancer-researchcopy/ddXxiaHj#
http://www.webspawner.com/users/introtoldn/index.html
These (below) are YouTube video clips on YouTube that are about LDN Therapy that you might find interesting......
http://www.youtube.com/watch?v=DAZ1fQKdOC8&feature=related (very good)
http://www.youtube.com/watch?v=FRI5f69N2eo&feature=related
http://www.youtube.com/watch?v=55562cy9fgQ&feature=related
http://www.youtube.com/watch?v=LT6J0M5GTQ4&feature=related
http://www.youtube.com/watch?v=CVpjsDK0LPA
And ----Tea...
You are taking doses WAY too wrong - WAT too imprecise.
If you take too little, LDN will NOT work...
If you take too much, you reverse the effects that you are seeking....
The way that you are taking it is way too much "rough guessing".
This IS the correct formula to follow EXACTLY) to make a 1 mg dose of LDN (so then you can try 2 mg or 3 mg or 4mg) - 1.5mg is the lowest that ANY of the expert doctors have found to work...
Anyone having "positive effects" on less than that is experiencing the "Placebo Effect":
http://www.webspawner.com/users/howtoobtainldn/index.html
QUOTE:
AllDayChemist (India) http://www.alldaychemist.com/single_product_detail.php?productid=1704&isProductID=156/1(The River Pharmacy buys their Naltrexone tablets from India and then resells them. At the present time, Naltrexone is manufactured by a number of different companies... *)
Once you have a supply of 50 mg Naltrexone tablets, you can convert them as needed to LDN. To do so, fill a graduated cylinder with 50 ml of distilled water (unlike tap or spring water, distilled water contains no impurities that could potentially react with and thus reduce Naltrexone's effectiveness). Pour the water from the graduate into a 4 oz amber glass jar with a tight-fitting lid. Then add a 50 mg Naltrexone tablet. The tablet will mostly dissolve in about five to ten minutes. Since not all of the tablet is soluble in water, instead of yielding a clear solution, the result will be a cloudy suspension. It must be shaken each time before use to evenly disperse all the undissolved particles. One ml of the (shaken) suspension will contain one mg of Naltrexone. Use a graduated baby medicine dropper to measure out the dose you need.
Once a drug passes from a solid to a liquid state, its shelf life can decrease dramatically. Therefore, do not make more than 50 ml of liquid Naltrexone at a time, store it in the refrigerator, and do not keep it for more than a month. The fresher the preparation, the better. Be sure to shake the liquid LDN well before using, and keep it from direct exposure to sunlight.
The medicine dropper should be available in the infant/baby section of your local pharmacy. If you ask politely and are lucky, the pharmacist may (as a gesture of good will) give you an empty 4 oz amber glass jar. Distilled water is sold by most pharmacies, as well as by supermarkets, hardware stores, and convenience stores.
(END QUOTE)One precaution to the above. After initially dissolving the tablet in the specified amount of distilled water and shake it thoroughly to insure the Naltrexone is fully dissolved and disperesed in the solution, do NOT shake it anymore (as in prior to using it). The sediment - particles in the solution when you shake it - are binder substance compounds and several manufacturers use a dietary form of iron powder as one of their binding agent components and that can adversely affect Lupus patients and others with similarly related disorders.
From the Yahoo Group on LDN Therapy:
QUOTE:
Subject: [lowdosenaltrexone] Naltrexone and solutionsFor those of you that prepare naltrexone from 50 mg tablets dissolved in water- I have a strong recommendation for you: do not shake the solution before use. Shake when you prepare it, but once the tablet is dissolved, there is no need to suspend the insoluble portions of the tablet.
This is fairly important for those with Crohn's, but possibly other diseases as well. If the tablet contains iron oxide (the ones we buy do), the iron is very hard on the system. Naltrexone is very soluble; it will already be in the solution- it does NOT settle out. But removing the iron oxide may help those with Crohn's.
I am an analytical chemist, and have discovered this by trial-and-error. Iron supplementation is strongly discouraged for those on the SCD- and there is a very good reason for that. The reason the body is iron-deficient is because it believes it is combating an infection. If the iron as supplements is withheld, one can consume iron-rich foods like red meat, eggs, liver, etc. If the iron is added- particularly as the iron oxide in naltrexone tablets- the result is pain and bleeding, even in very small amounts.
Again- I'm a chemist by training. If you make your own solution, PLEASE do not consume the insoluble sediment. There is absolutely no need to shake the solution right before you consume it- only when you're preparing it for the first time- as the naltrexone is already dissolved.
I hope this helps someone somewhere. Good luck, and best wishes.
END QUOTE(*) The pills you are taking - even though manufactured in India, ALL of them are destined to also be sold under American brand names - and consist of pure Naltrexone Hcl USP, plus whatever used binders - it is the binders that do no dissolve fully in the distilled water, and it must be DISTILLED water... for the formula to work correctly (only as certain mineral content of some tap waters may have compounds which release cause the Naltrexone to dissolve too slowly... it should dump into your system in a rush ... and in that matter, the DIY formula is actually better than the pharmacy compounded tablets.
poster:Elroy
thread:919880
URL: http://www.dr-bob.org/babble/20091227/msgs/931844.html