Re: Diphenhydramine an antidepressant?

Posted by linkadge on December 27, 2009, at 12:01:56

In reply to Re: Diphenhydramine an antidepressant?, posted by bleauberry on December 27, 2009, at 6:18:28

Yes, benadryl does have some antidepressant effect. It has activity as a SSRI. Studies suggest that it is active in animal models of depression and anxiety.
I think the main reason it has never been presued or promoted as an AD was because of:
a) its availablilty
b) its anticholinergic/antihisaminergic side effects
c) the developement of derivitives (ie prozac) that were cleaner and to be made available by prescription.
As mentioned the antihistamine chlorpheniramine also has AD properties. I think with chlorpheniramine, the ratio of SSRI action to other receptors is higher.
Linkadge

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Diphenhydramine an antidepressant? highhatsize 12/26/09
Re: Diphenhydramine an antidepressant? » highhatsize janejane 12/26/09
Re: Diphenhydramine an antidepressant? sam K 12/26/09
Re: Diphenhydramine an antidepressant? highhatsize 12/26/09
Re: Diphenhydramine an antidepressant? » highhatsize Phillipa 12/27/09
Re: Diphenhydramine an antidepressant? bleauberry 12/27/09
Re: Diphenhydramine an antidepressant? linkadge 12/27/09
Re: Diphenhydramine an antidepressant? highhatsize 12/27/09
Re: Diphenhydramine an antidepressant? » linkadge SLS 12/27/09
Re: Diphenhydramine an antidepressant? » highhatsize SLS 12/27/09
Re: Diphenhydramine an antidepressant? highhatsize 12/27/09
Re: Diphenhydramine an antidepressant? highhatsize 12/27/09
Re: Diphenhydramine an antidepressant? » highhatsize SLS 12/27/09
Re: Diphenhydramine an antidepressant? highhatsize 12/27/09
Re: Diphenhydramine an antidepressant? janejane 12/27/09
Re: Diphenhydramine an antidepressant? highhatsize 12/27/09
Re: Diphenhydramine an antidepressant? » highhatsize bleauberry 12/28/09

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