Posted by SLS on November 25, 2009, at 23:10:24
In reply to Re: klonopin success and then the other way!, posted by mogger on November 25, 2009, at 22:52:48
> Very interesting scott, I will speak with my doctor about this. Thanks very much
Here's one to show your doctor if he is interested:
- Scott
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Clonazepam-induced up-regulation of serotonin1 binding sites in frontal cortex of ratH. R. Wagner2, 1, A. Reches2 and S. Fahn2
1 Departments of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, U.S.A
2 Departments of Neurology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, U.S.A
Accepted 18 February 1985.
Available online 6 November 2002.Abstract
Chronic administration of the benzodiazepine, clonazepam, increased the number of [3H]-hydroxytryptamine (5-HT1) binding sites in the frontal cortex of the rat. The increase reflected a change in the maximum density of binding sites (Bmax) with no change in ligand affinity (Kd). Increased binding occurred after continued exposure (10 days) to large (5.0 mg/kg) doses of clonazepam. The changes in [3H]5-HT binding were regional in that they occurred in membranes from the frontal cortex but not the brainstem. The effects were also at least partially selective for 5-HT receptors since the binding of the β-adrenergic radioligand, [3H]dihydroalprenolol, was not affected by clonazepam. A second benzodiazepine, diazepam, did not affect the binding of [3H]5-HT at doses of 30 mg/kg per day. The latter data suggest that the effects of benzodiazepines on serotonin 5-HT1 receptors are unique to clonazepam.
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poster:SLS
thread:926987
URL: http://www.dr-bob.org/babble/20091117/msgs/926999.html