Posted by SLS on November 23, 2009, at 7:27:00
In reply to Re: Treatment resistant OCD, posted by hopefullynow on November 23, 2009, at 5:54:43
Neither Celexa nor Lexapro inhibit CYP450 2D6 at all. So, Lexapro might make an ideal drug to combine with full therapeutic dosages of Anafranil. The study I cited used Celexa, but with only 75mg of Anafranil. 250mg should have been the maximum dosage tested.
With Paxil, the dosages of TCA should be reduced by 50%. That would indicate that dosages of Anafranil up to 125mg can be used. Prozac is a less potent 2D6 inhibitor than is Paxil, so the same 50% dosage reduction formula should be safe.
If it were me, I would use the maximum dosages of those SSRIs that have shown efficacy in treating OCD, and gradually titrate the Anafranil afterwards.
- Scott
poster:SLS
thread:926438
URL: http://www.dr-bob.org/babble/20091117/msgs/926681.html