Posted by conundrum on November 16, 2009, at 22:19:57
In reply to trazadone not effective?, posted by JohnnyBLinux on November 14, 2009, at 23:15:52
It could be the med. I believe trazodone metabolizes into another drug that does the opposite of what the original drug does.
This is from wikipedia, so its not necessarily reliable. I would do some research on your own about the metabolites of trazodone and ask your doctor. Here is the quote:
"Trazodone is well absorbed after oral administration with mean peak blood levels obtained at approximately 1 hour after ingestion. Absorption is somewhat delayed and enhanced by food. The mean blood elimination half-life is biphasic: the first phase's half-life is 3–6 hours, and the following phase's half-life is 5–9 hours. The drug is extensively metabolized with 3 or 4 major metabolites having been identified in the human body, some of which such as mCPP[17] may contribute to the side effect profile of trazodone. mCCP has been shown to activate numerous serotonin receptors, including 5ht2c. Due to the short half-life of trazodone, if a dose is taken at night, mCCP would be present in the body during the following day, causing symptoms such as anorexia (behavioral symptoms), ANXIETY, hypolocomotion, headache, and DEPRESSION. Approximately 70–75% of 14C-labelled trazodone was found to be excreted in the urine within 72 hours.[18] Trazodone is highly protein-bound."
I highlighted portions for emphasis. Hopefully you find something that helps without making you depressed.
poster:conundrum
thread:925773
URL: http://www.dr-bob.org/babble/20091107/msgs/925988.html