Posted by southernsky on November 15, 2009, at 20:58:11
In reply to I don't sweat, posted by linkadge on November 15, 2009, at 7:51:49
Just be careful!
Drugs that induce hypohidrosis, or deficient sweating, can increase the risk of heat exhaustion or heat stroke and include antimuscarinic anticholinergic agents, carbonic anhydrase inhibitors and tricyclic antidepressants. As acetylcholine is the principal neuroeccrine mediator, anhidrosis is one of the clinical hallmarks by which acute anticholinergic toxicity may be recognized. The symptom of dry mouth often accompanies the less apparent symptom of hypohidrosis because the muscarinic M3 acetylcholine receptor type predominates at both sweat and salivary glands. Management options include dose reduction, drug substitution or discontinuation. When compelling medical indications require continuation of a drug causing hyperhidrosis, the addition of a pharmacological agent to suppress sweating can help to reduce symptoms. When hypohidrotic drugs must be continued, deficient sweating can be managed by avoiding situations of heat stress and cooling the skin with externally applied water. The availability of clinical tests for the assessment of sudomotor dysfunction in neurological disease has enhanced recognition of the complex effects of drugs on sweating. Advances in the understanding of drug-induced anhidrosis have also enlarged the therapeutic repertoire of effective treatments for hyperhidrosis.
http://www.ingentaconnect.com/content/adis/dsf/2008/00000031/00000002/art00002
DISORDERS OF SWEATING AND THERMOREGULATION.Article
CONTINUUM: Lifelong Learning in Neurology. 13(6) Autonomic Disorders:143-164, December 2007.
Cheshire, William P.; Low, Phillip A.Abstract:
The autonomic nervous system strictly maintains internal body temperature within a narrow margin of 37[degrees]C. Diseases and the drugs used to treat them can impair thermoregulation at many levels, including afferent thermoreception, the hypothalamus, descending vasomotor and sudomotor pathways, spinal intermediolateral cells, sympathetic ganglia, peripheral autonomic nerves, and the neuroeccrine junction. The brain, which is especially vulnerable to the physiologic stresses of hypothermia and hyperthermia, coordinates the vasomotor and sudomotor responses that retain or dissipate bodily heat. Numerous disorders are associated with hyperhidrosis and hypohidrosis. Some disrupt thermoregulation, and others are socially troubling, while most provide informative diagnostic clues.(C) 2007 American Academy of Neurology
poster:southernsky
thread:925801
URL: http://www.dr-bob.org/babble/20091107/msgs/925881.html