Posted by Phidippus on October 30, 2009, at 16:06:37
In reply to Mood stablization, posted by willyeee on October 30, 2009, at 11:01:22
> my mood is much more stable knock on wood,i love gaba lol !
Zonisamide blocks sodium channels and reduces voltage-dependent, transient inward currents (T-type Ca2+ currents), consequently stabilizing neuronal membranes and suppressing neuronal hypersynchronization. Zonisamide does not appear to potentiate the synaptic activity of GABA. Zonisamide binds to the GABA/benzodiazepine receptor ionophore complex in an allosteric fashion which does not produce changes in chloride flux. Zonisamide facilitates both dopaminergic and serotonergic neurotransmission. Zonegran also enhances the uptake of the excitatory neurotransmitter glutamate.
IN OTHER WORDS, Zonegran does a bunch of things and most likely helps stabilize mood through blockade of sodium channels and by facilitating seratonin transmission. Mania has been reported on ZOnegran as a consequence of increased dopaminergic transmission. By binding to GABA and facilitating glutamate reuptake, Zonegran might be exhibiting anxiolytic properties.
Where is your rage coming from? If you're on Parnate, then I doubt the rage is IED (intermittent explosive disorder)-this is treated with antidepressants and Lithium (have you ever been on Lithium?) which leaves me to think you are bipolar and the 'cycling' of rage is your mood cycling. Zonegran is WELL down the list of mood stabilizers and there others that may work better for you. Have you even ever tried an atypical antipsychotic?
Are you going into rages for no good reason or is it something you're thinking about?
P
poster:Phidippus
thread:923504
URL: http://www.dr-bob.org/babble/20091029/msgs/923538.html