Posted by desolationrower on September 16, 2009, at 17:48:25
In reply to Re: meds + restless leg » g_g_g_unit, posted by sowhysosad on September 16, 2009, at 11:23:18
> > forgive my naivete, but i thought since Parnate increases dopamine, it would help combat the RL. maybe my dose (20mg) is too low for much MAO-B inhbition?
>
> But the Seroquel will be occupying the dopamine receptors associated with movement in the substantia nigra and nigrostriatal pathway, particularly at night when you've just taken a dose.
>
> So the dopaminergic effects of the Parnate will be blocked.a2 block increases cortical DA, as does 5ht2 blx. low doses could help, although you could have catecholamine increases while the reeptors are blocked, and i forget what brain region matters for RLS
heres a study availible that shows thing though its not the main point of the study http://www.aapsj.org/view.asp?art=aapsj080226
remember also that quetiapine isn't a strong dA blockers (see also: it sucks for reducing positive symptoms)
-d/r
poster:desolationrower
thread:916925
URL: http://www.dr-bob.org/babble/20090912/msgs/917386.html