Posted by iforgotmypassword on August 31, 2009, at 19:25:14
In reply to Re: is abilify a post-synaptic D2 antagonist in pfc?, posted by desolationrower on August 30, 2009, at 17:45:48
in some cases it's an agonist, based on it's occupancy and it being far less an agonist than DA, it's technically lowering dopaminergic agonism in general, and others cases not.
though apparently this differs regionally.
in many cases it isn't even an agonist to start with but a straight post-synaptic antagonist (e.g. in the striatum), so i am wondering what is its effects specifically are, in terms of intrinsic efficacy (as an agonist or antagonist) in the PFC, or in different parts of the PFC.
poster:iforgotmypassword
thread:914905
URL: http://www.dr-bob.org/babble/20090826/msgs/915127.html