Posted by yxibow on August 23, 2009, at 0:37:46
In reply to 5 yr old fluvoxamine, what could be wrong with it?, posted by iforgotmypassword on August 21, 2009, at 17:52:09
> other than reduced potency (by how much) is there any danger? i would be doing this having taken selegiline regularly at 5-10mg, haven't taken it today.
The key is regularly...
> i want to do an experiment one dose of 25mg-50mg fluvoxamine + 10-20mg buspirone.
DONT. You risk a hypertensive crisis. Why mess around with that. Do you have 5 year old nifedipine ?Admittedly 25mg of Luvox will do almost nothing for you psychotropically since a typical working dose starts close to 200mg, but why risk yourself?
As for the "5 year issue"... I don't see the problem with it since today medications are labeled from pharmacies 18 months +. And then of course there are the army tests of a selective set of medications, which doesn't prove that yours is the same result though.
If you haven't stored it in a humid bathroom "medicine cabinet" (bad place to actually store medicine) or left it sitting in a hot car or out of the range of say 40 to 90 degrees F for long periods of time, 5 years is really insignificant then.But if its crumbly, don't quote me on that.
> by my crumby logic, it may help me know for sure if tandospirone is the response i should be chasing, by letting serotonin do its work specifically in the frontal cortex. it's very shoddy, but it's the best i have right now, aside from another trial of buspirone + grapefruit juice that will take days to figure out, and then there's always the D2 risk.Why take BuSpar and grapefruit juice to trick your P450 system instead of a larger dose of BuSpar?
> this i imagine will help me know if my only real option is tandospirone or *possibly* maybe something like fluoxetine (not fluvoxamine) + buspirone, but i worry about SSRIs long term.
Well, SSRIs can be used safely for years -- for some people, they probably have been on Prozac or Luvox since they came out... some fit into the class of what is colloquially called "poop out", which really means that transmitters have been hyper-extended.A flushout may or may not allow this to heal (neuroplasticity). Responses to further SSRIs may require greater amounts or a diffent SSRI.
This isn't a comment on their "safety" -- its just a theoretical scenario.
>i think one trial is safe, otherwise i worry about long term issues, esp. since paroxetine is the drug that started all of my movement issues (possibly in concert with low dose chlorpromazine)
I think the Thorazine is far more likely for any movement culprits.
Yes, SSRIs can potentially increase the risks of movement disorders when combined with APs... but there are reasons for doing that combination, such as in psychotic cases of OCD.
I believe they have caused things for me (still have a tic on my right index finger from Risperdal and Prozac after only about two weeks + discontinuation 8 years later -- though my doctor disagrees with the assesment.. .yes, there is causality and causation but its pretty obvious in my mind).... this is for an entirely different situation than I noted above.-- Jay
poster:yxibow
thread:913372
URL: http://www.dr-bob.org/babble/20090818/msgs/913581.html