Posted by offwhite on July 30, 2009, at 6:26:33
(I'll just copy my post on imminst to this board for more answers and discussions, I think it's an interesting idea and want to see if anyone else has tried/thought about it...)
I have recently started taking the new AD agomelatine which is an mixed melatonin-agonist and 5-ht2c-antagonist.
Antagonism of the 5-ht2c-receptor seems to increase prefrontal levels of dopamine and noradrenaline and has anxiolytic effects.
I heard that at low doses, fluoxetine (aka prozac) has antagonistic properties at the 5-ht2c-receptor, well before the serotonin transporter is affected.Does anybody know how low dosage you should take to benefit from this effect while avoiding any effect on the SERT-transporter?
I was thinking about combining Agomelatine (pro-sleep+5ht2c-antagonism), with selegiline (low dose to avoid MAO-A-inhibition) and fluoxetine for added 5ht2c-antagonism.
poster:offwhite
thread:909251
URL: http://www.dr-bob.org/babble/20090721/msgs/909251.html