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5--ht2c-antagonistic effects of Fluoxetine(prozac)

Posted by offwhite on July 30, 2009, at 6:26:33

(I'll just copy my post on imminst to this board for more answers and discussions, I think it's an interesting idea and want to see if anyone else has tried/thought about it...)


I have recently started taking the new AD agomelatine which is an mixed melatonin-agonist and 5-ht2c-antagonist.
Antagonism of the 5-ht2c-receptor seems to increase prefrontal levels of dopamine and noradrenaline and has anxiolytic effects.
I heard that at low doses, fluoxetine (aka prozac) has antagonistic properties at the 5-ht2c-receptor, well before the serotonin transporter is affected.

Does anybody know how low dosage you should take to benefit from this effect while avoiding any effect on the SERT-transporter?

I was thinking about combining Agomelatine (pro-sleep+5ht2c-antagonism), with selegiline (low dose to avoid MAO-A-inhibition) and fluoxetine for added 5ht2c-antagonism.


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