Posted by SLS on July 30, 2009, at 5:44:58
In reply to Re: vilozodone » SLS, posted by iforgotmypassword on July 29, 2009, at 18:36:59
> > and a partial agonist of 5-HT1a receptors.
>
> in vivo? is this 100% clarified now?I didn't know there had been some question regarding this. I haven't looked for corroborative evidence of it, though. Since so many studies presume 5-HT1a agonism to be a mechanism, I figured it was considered putative.
It has happened before that the scientific community stated that a particular property of a drug was putative, relying on a single study to determine this. Provigil is an example of this. 5-10 years ago, it was touted as being a NE alpha-1 agonist by all published papers. The origin of this mistaken notion came from one or two preliminary studies.
- Scott
poster:SLS
thread:909160
URL: http://www.dr-bob.org/babble/20090721/msgs/909248.html