Posted by yxibow on July 14, 2009, at 11:34:38
In reply to 2 Anti-psychotics?, posted by SheilaC on July 10, 2009, at 7:00:37
Its not necessarily the "harsh side effects", but
that two or more antipsychotics, while maybe not having a medication database drug-drug interaction, nonetheless enter uncharted territories with a mix of receptor antagonism/blockade that should be watched.
It is quite likely that you may be experiencing akathisia from Abilify -- its not always the D2/D2 push-me/pull-you panacea that it was touted to be... at least for me it was in the mid to mid-higher spectrum of that.But I'm sensitive to APs and strong(er) ones usually produce akathisia.
As for serotonin... atypical APs affect their level. That's what makes them atypical, their 5HT(2):D2 ratio.
Nonetheless their effects on 5HT are different typically than SSRIs, they form a receptor blockade, such as what trazodone/nefazodone does in some regards, and Remeron partially.
Since you said you've been through old antidepressants I assume you mean tricyclics such as amitriptyline which have been in use for Interstitial Cystitis.There are some other treatments too, antihistamines and more esoteric ones, but I'm sure you're aware of this having this condition.
But, if this combination works for you, so much the better. Its a pretty low dose of both medications and a modest dose of Klonopin.
-- tidings
-- Jay
poster:yxibow
thread:905992
URL: http://www.dr-bob.org/babble/20090709/msgs/906722.html