Posted by Jimmyboy on May 14, 2009, at 11:02:41
In reply to Re: Little more - thc/kappa or, posted by desolationrower on May 14, 2009, at 1:37:44
Well this is from wikipedia
Cannabis sativa
"The active component of cannabis, THC, is a partial kappa-opioid agonist and may account for the aversive affects of "paranoia" experienced during its use as well as some non-addictive properties of cannabis.[53][54]"
These are what they cite:
Smith PB, Welch SP, Martin BR (March 1994).
"Interactions between delta 9-tetrahydrocannabinol and kappa opioids in mice". The Journal of pharmacology and experimental therapeutics 268 (3): 13817. PMID 8138952.
http://jpet.aspetjournals.org/cgi/content/abstract/268/3/1381
^
Hampson RE, Mu J, Deadwyler SA (November 2000)."Cannabinoid and kappa opioid receptors reduce potassium K current via activation of G(s) proteins in cultured hippocampal neurons". Journal of neurophysiology 84 (5): 235664.
PMID 11067978http://jn.physiology.org/cgi/content/abstract/84/5/2356
As well as this:
The Journal of Neuroscience, February 1, 2002, 22(3):1146-1154
Motivational Effects of Cannabinoids Are Mediated by µ-Opioid and -Opioid Receptors
Sandy Ghozland1, Hans W. D. Matthes2, Frederic Simonin2, Dominique Filliol2, Brigitte L. Kieffer2, and Rafael Maldonado1"...protocols that reveal both THC rewarding and aversive properties. Absence of µ receptors abolishes THC place preference. Deletion of receptors ablates THC place aversion and furthermore unmasks THC place preference. Thus, an opposing activity of µ- and -opioid receptors in modulating reward pathways forms the basis for the dual euphoric-dysphoric activity of THC. "
I got this from a thread at mind and muscle which has more info
http://www.mindandmuscle.net/forum/index.php?showtopic=36315&st=0&gopid=550105&#entry550105
poster:Jimmyboy
thread:895287
URL: http://www.dr-bob.org/babble/20090505/msgs/895760.html