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Re: Ketamine - OR - what about high dose Memantine? » uncouth

Posted by yxibow on April 28, 2009, at 21:41:18

In reply to Ketamine - OR - what about high dose Memantine?, posted by uncouth on April 28, 2009, at 19:42:36

> Ok, then if the guidance is to stay away from Ketamine as a risky compound for killing this depression, what about ultra-high-dose Memantine? Anyone know if that's worth trying, or if the pharmacokinetics even make such an attempt workable? I'm currently at 40mg and honestly I can't really tell what affect if anything it is having, I take 20mg 2x a day, but have only been on it for a month as I was able to convince my pdoc to Rx me Namenda to help with ECT cognitive side effects.
>
> SO if anyone knows anything about high dose memantine....please do share!


I would say its an entirely personal experience. Namenda is not an innocuous medication (neither is Deplin which I forget what also it did to me at the moment). I too tried it for cognitive issues, related to the dose of Valium that I have catch-22 issues but still need to take at the moment.

When I got to 20mg, my complex somatoform / anxiety / etc disorder got to the intensely unpleasant experience.

As soon as it was dropped, within a matter of a week or less symptoms were down again. I was disappointed but it wasn't worth continuing to find out with that sort of result that caused a large spike in anxiety.

But as they say, each to their own. Maybe it will help you. As for side effects outside of magnifying my illness, or benefits, there weren't any. 40mg sounds a bit excessive, but I know that I am a fast metabolizer of some things.

-- Jay

 

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URL: http://www.dr-bob.org/babble/20090426/msgs/893380.html