Posted by sowhysosad on April 2, 2009, at 17:48:44
In reply to Bupropion - norepinephrine uptake, posted by sowhysosad on April 2, 2009, at 17:42:48
> > That's interesting--are you sure about the source? I was on bupropion for awhile and it was definitely a dopamine drug for me. The experts on babble should be able to weigh in here.
>
> I may have read it on Dr Ken Gillman's psychotropical site, but upon searching all I can find is this:
>
> http://www.psychotropical.com/Antidepressants_Bupropion_Zyban.shtml
>
> He doesn't mention the active metabolite's affinity for the norepinephrine transporter in that article, but he does say it's only a weak DRI but probably has some other unknown dopamine-enhancing effect.
>
> I've read elsewhere that bupropion is also a weaker DRI than sertraline, interestingly.Ah! Hang on - try this article from the highly-regarded psychopharmaceutical source "Bodybuilding.com":
http://www.bodybuilding.com/fun/par13.htm
"most of bupropion's "antidepressant" action is attributed to its noradrenergic mechanisms. How can this be? Bupropion's active metabolite, hydroxybupropion has almost equal affinity for the NA re-uptake pump as bupropion yet its concentrations during clinical treatment reach 6-fold that of the parent drug"
poster:sowhysosad
thread:887980
URL: http://www.dr-bob.org/babble/20090330/msgs/888269.html