Posted by myco on April 1, 2009, at 13:10:38
In reply to Re: Parnate: No Libido and Sleeping all the Time?!?!?, posted by Phillipa on April 1, 2009, at 12:57:30
> Seems quite a few for various reasons have returned to SSRI's from the Maoi's why is that if they are the strongest? Or aren't they? Phillipa
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They arent the strongest hun...nor should they be considered last line treatments.Back in the day when they were developing meds they had ideas about what depression was but nothing was really clear, as far as I know...I dont think they knew the potential heavy influence of seratonin on depression.
The old maois used the "shot gun" approach (an old term coined years ago)...they just hit everything and by hitting lots of different neuros and having other effects they found potential usefullness. As far as I know these were compounds being designed for use in the elderly/parkinsons patients...they had the connection of dopamine and parkinsons back then...L-Dopa was being studied in the 60s I think perhaps even before. Well the old maois produced side effects in these parkinsons patients (or was it alzheimers...cant remember) like happyness etc....so hense was born one of the first categories of antidepressant.
Jan since no one knows exactly what your particular issue is with neuros...the maois are a good option (for anyone really...not all are hardcore like parnate and nardil, im sorry but no one will convince me, is no way a hardcore med - mild! mild! after you stabilize). Maois will go and hit everything for you...almost everyone who is considered "atypical" in depressive issues will see some benefit (varies) with maois...serious.
They arent strong than ssri's...just not directed at anything specific (ssri's almost exclusively seratonin with indirect effects on da or ne) and come with a few risks that scare drs....but seriously...i mean they the diet clear and what OTC meds you can take...only people uncaring or not paying attention would mess this up...so you cant have aged cheese and other fermented or aged foods and you have to deal with a cold other ways....for the benefit that a maoi can potential provide?...no issue here at all.
poster:myco
thread:888039
URL: http://www.dr-bob.org/babble/20090330/msgs/888065.html