Posted by myco on March 31, 2009, at 11:53:08
In reply to Re: Long term MAOI use slows DA system firing rates, posted by desolationrower on March 31, 2009, at 4:19:49
lol now i'm overly interested. Nardil is slowing in efficacy in terms of energy and concentration...still excellent for anxiety although breakthroughs do happen. I had always thought that the DA/NA effect was the issue with this now it seems it's a likely possibility and 'treatable' without stimulants...hmm wonder if I can "gp word" this correctly as to not put him off.
> > d/r,
> >
> > Not to sound dense here (it's after 1am and i'm tired)...um:
> >
> > "Since ondansetron completely reversed the effects of clorgyline on DA neuronal activity, the effects of MAOA inhibition appeared to be mediated by 5-HT3 receptors."
> >
> > Youre saying that adding memantine or ondansetron or another compound that antagonizes 5-ht3 (blocks 5ht3) will reverse some of the DA attenuation caused by prolonged use of a MAOI?
>
> htats what i think that paper says.
>
> > Also...Can you tell me what memantine does for you...like does it bring back a lost effect you had on parnate?
>
> not much, maybe a bit more solid antidepressant effect (i'm pretty med insensitive tho)
>
> -d/r
poster:myco
thread:887823
URL: http://www.dr-bob.org/babble/20090330/msgs/887883.html