Posted by Vincent_QC on January 25, 2009, at 14:26:09
In reply to Re: Making sense of NARDIL 'poop out' (benzo like?), posted by desolationrower on January 25, 2009, at 10:50:25
> phenibut seems to get tolerance quite quickly, so gaba-b might be related to part of whats going on.
>
> -d/rHummm, we talk about the Nardil effect on the Gaba-B...Phenibut seem to me not very use around the world...I don't know someone who still use it in fact...What I found about Phenibut explain the fast tolerance about THAT specific drug...but that's not necessary apply to the Nardil effect on the gaba-b type...For this reason, I don't think the poop-up effect of the Nardil is related to his gaba-b effect...In fact, Nardil increase the level of gaba-b...but the main action of the Nardil is on the SE, NE and DA....the gaba-b is an extra...We can argue a long time on this...but for the little I know about the Nardil...I don't think we can compare it to the Phenibut...or any others anticonvulsives drugs like Lyrica or Gabapentin...even Baclofen...Anyway, tolerance always occur with drugs at one point...but that's not pointing necessary to the GABA-B effect of the Nardil... IF so, why the Parnate have a HIGH tendency to poop-up after a couple of days??? We even don't know if the Parnate act on the gaba-b... I really don't think it's related anyway...
Like I wrote before, the benzo drugs are not the same...it's gaba-A effect... Differents drugs and also differents rings attached to the gaba-A receptors act differently on a person...I try the Frisium (CLobazam), aparrently, it was a 1-5 gaba-a type...affecting differents sites of the gaba-a receptor...and that drug never relief me of my anxiety...normal benzo drugs or the more common have a 1-4 structure... Anyway, i'm not a Doctor or a pharmacist...but I know one thing, I experienced a lot of benzo drugs and anticonvulsives drugs who acts on gaba-a or gaba-b and i'm sure tolerance can occur at one point...but that's different from people to people...the same apply to people who take Rivotril for several years without any addiction problem and others like me who get addicted after 1 month on it...and even if the double dosage , never reach a the same level of relief on the anxiety after...
"Tolerance develops to many of the effects of phenibut, although it is reported that it does not develop to the nootropic effect. The first signs of tolerance may be seen within as little as five days. For this reason, it is commonly used for one to two week periods, or dosage is increased by 25-30% after two weeks [2]. This makes phenibut ideal for short periods of stress or anxiety, but not ideal for chronic use. It is possible that taking only one dose daily may partially reduce the development of tolerance.
Persons on MAO inhibitors or epilepsy medications like carbamazepine or oxcarbazepine should consult with their psychiatrist/physician prior to supplementation with phenibut. Clinical research has demonstrated that phenibut can potentate or inhibit the function of some epilepsy medications."
poster:Vincent_QC
thread:875681
URL: http://www.dr-bob.org/babble/20090104/msgs/876105.html