Posted by SLS on January 10, 2009, at 13:01:02
In reply to Re: Moclobemide or Stablon: Which is more effective?, posted by SLS on January 10, 2009, at 12:28:12
> Hi.
>
> > Both drugs i would consider weaker but useful for their lack of side effects. The sort of drugs that should be first-line prescriptions by GPs.
>
> For a number of years, moclobemide was the most widely prescribed antidepressant in various countries around the world. It became popular because its side effect load was low and the onset of clinical improvement was seen very early in treatment (often in the first week). However, it has fallen quickly out of favor for lack of efficacy when used long-term and the need to continually escalate the dosage to retain a therapeutic effect. Moclobemide poops-out more than any other antidepressant I can think of.
>
> Roche, the manufacturer of moclobemide, was forced to discontinue their project to have the drug approved in the U.S. Their U.S. studies, as mandated by the FDA, could not demonstrate efficacy.
Phillipa:I don't know if you can find this information on the Internet. I spoke directly to the project manager at Roche shortly after the decision had been made to discontinue investigations with moclobemide. They even tried to get it approved for social phobia. Again, it proved to be ineffective.
- Scott
poster:SLS
thread:873128
URL: http://www.dr-bob.org/babble/20090104/msgs/873156.html