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Re: Treatment Resistant (Refractory) Depression » CaptainAmerica1967

Posted by SLS on December 14, 2008, at 8:26:15

In reply to Re: Treatment Resistant (Refractory) Depression, posted by CaptainAmerica1967 on December 13, 2008, at 15:33:09

> Did it work well for you?

As monotherapy, it produced episodic robust improvements, but proved to be an untenable therapy. I wish I were allowed by the NIMH protocol to add a therapeutic dosage of desipramine.

In my opinion, clorgyline, a specific MAO-A inhibitor, is the single most effective antidepressant in the world. It was considered by the NIMH to be their "ace-in-the-hole" when all else failed. Many people remained well on clorgyline for over a decade. Unfortunately, several people experienced cardiovascular events that convinced the NIMH to no longer support its use. It is unclear if these treatment-emergent events were caused by clorgyline.

Clorgyline is no longer manufactured for human consumption, but remains the paradigm for assaying MAO-A activity.

I don't think I would trust anyone to synthesize this particular chemical such that I would pass it down my throat. I wouldn't know how to find such a person, anyway.


- Scott

 

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