Posted by uncouth on October 23, 2008, at 10:44:06
Hi, I was advised to ask this question again as I didn't get too many responses when I asked two weeks ago.
I'm currently taking 40mg of Parnate and took Emsam in the past, and did well on Emsam but the anxiety was too much to handle. Anxiety has been better on Parnate and overall I like it better, but I have done lots of research on selegiline and know it to have some very unique neuroprotective and neurotrophic properties, independent of it's MAO-B inhibition, that Parnate may not have.I'd like to add a very low dose of oral selegiline (tablets) to my daily dose of Parnate. Is this is a safe thing to do? I was thinking 2.5mg. I realize I could simply increase my dose of Parnate, but I've had bad orthostatic hypotension on higher doses, and am looking to take the additional selegiline as a neuroprotectant and to improve residual anhedonia.
I'd love feedback on this idea. Is 2.5mg daily enough to make a difference? Is it too much? Is daily dosing necessary? Will this screw with Parnate? If 2.5mg is enough to have an affect on MAO-B, does that mean the dose of Parnate will be more biased towards MAO-A inhibition?
Or is this just a bad idea at any dose?
Would liquid selegiline (cyprenil) be a better choice, as as far as I know, it doesn't convert into amphetamine like oral selegiline does....right?
poster:uncouth
thread:858948
URL: http://www.dr-bob.org/babble/20081016/msgs/858948.html