Posted by Shelly Dylan on October 8, 2008, at 9:44:41
In reply to Re: Need Help Obtaining Suboxone » Shelly Dylan, posted by azalea on October 7, 2008, at 19:01:56
> Perhaps you could provide your doctor with following research study . . .
>
> J Clin Psychopharmacol. 1995 Feb;15(1):49-57.
>
> Buprenorphine treatment of refractory depression.
>
> Bodkin JA, Zornberg GL, Lukas SE, Cole JO.
> McLean Hospital, Consolidated Department of Psychiatry, Harvard Medical School, Belmont, MA 02178, USA.
>
> Opiates were used to treat major depression until the mid-1950s. The advent of opioids with mixed agonist-antagonist or partial agonist activity, with reduced dependence and abuse liabilities, has made possible the reevaluation of opioids for this indication. This is of potential importance for the population of depressed patients who are unresponsive to or intolerant of conventional antidepressant agents. Ten subjects with treatment-refractory, unipolar, nonpsychotic, major depression were treated with the opioid partial agonist buprenorphine in an open-label study. Three subjects were unable to tolerate more than two doses because of side effects including malaise, nausea, and dysphoria. The remaining seven completed 4 to 6 weeks of treatment and as a group showed clinically striking improvement in both subjective and objective measures of depression. Much of this improvement was observed by the end of 1 week of treatment and persisted throughout the trial. Four subjects achieved complete remission of symptoms by the end of the trial (Hamilton Rating Scale for Depression scores < or = 6), two were moderately improved, and one deteriorated. These findings suggest a possible role for buprenorphine in treating refractory depression.
>
> > I've suffered from severe refractory depression for over 21 years. The only thing that works are opiates. They make me feel normal not high. I can't find a doctor who will prescribe them to me thanks to our "wonderful" DEA. What do I do? I need help. I don't want to live the rest of my life depressed. I don't understand how physician's, in part thanks to the government, can refuse to give me medicine that will help my condition. Someone, anyone, please help.
>
> I've already shown my doctors and psychiatrists the "Bodkin Experiment" along with pages of other documents that support the idea of a subtype of depression that involves the endogenous opioids be it a lack of enkephalins or some problem with the opioid receptor sites, etc. They immediately get defensive. I work in the medical field myself and doctors don't like patients who "try to dictate their own treatment". It doesn't even matter to these doctors that I have been on every antideppressant, antipsychotic, antianxiolytic, and combinations of all the above over the past 21 years. My current psychiatrist is telling me that I need to try ECT and if that doesn't work then she will "think about opiates". I'm not undergoing ECT when the medical community can't even give anyone an explanation for how ECT works. I also feel my rights are being violated by my doctor telling me to go get ECT and then if that doesn't work opiates "might be tried". It's like some sort of sick bribe.
poster:Shelly Dylan
thread:856260
URL: http://www.dr-bob.org/babble/20081006/msgs/856382.html