Posted by Tony P on September 24, 2008, at 2:56:47
In reply to Re: Reboxetine vs Effexor, Cymbalta » Tony P, posted by azalea on September 23, 2008, at 15:48:33
> I don't think Reboxetine would be a good substitute for Cymbalta. Cymbalta inhibits norepinephrine and serotonin reuptake, while reboxetine inhibits norepinephrine reuptake only. Perhaps combining Lexapro + Reboxetine would be a good solution. Kind of like making your own Cymbalta.
TP} Lexapro may well be the best choice - v. low side effects when I took it before, except for the usual SSRI sexual S/E.
>
> Also, are you taking both Seroquel and Remeron at night? This could cause hypersomnia.
>
TP} Yes lately I have been taking both Seroquel & Remeron at night - the Remeron seems to have lost some of its sleep-inducing effect, but I also think you're right & the combination (esp. with 50 mg or more Seroquel) is driving the hypersomnia -- I graphed it in Excel and the increase in average Seroquel pretty much mirrored the hypersomnia.> Have you tried Wellbutrin (buproprion)? It is generally an energizing anti-depressant, best taken in the morning.
TP} Yes, tried it several times a few years ago. I like what it does for me, but I am abnormally sensitive to it, so the generally recommended dose (300 mg/day) drives me into full mania (I didn't believe it, but my family let me know - independently - in no uncertain terms that I was acting crazy!) I can tolerate about 25-50 mg/day, maybe 75 mg tops, but it's only available nowadays, in Canada at least, in SR or long-acting dose forms that are larger than that. I tried splitting the tabs, even though you're not supposed to, and that was fairly OK. Still experienced quite a lot of anxiety & insomnia even at low doses. However, maybe it's worth another try. I'll double-check with my pharmacist (who is always very helpful) whether they can get any low dose or splittable short acting tabs.My MD is away but I'm going to see whoever's on duty at his clinic today or tomorrow, and I have an appointment with a government-funded counselor that I hope will lead to a referral (fairly promptly) to a staff psychiatrist. Experimenting with a statistical sample of one is interesting for a while, but internet drugs are e-x-p-e-n-s-i-v-e, even presuming you find a reliable source, whereas at least some of my meds are covered by the govt. (not Cymbalta, though, - it's too new in Canada & is probably being classed as a "me-too" substitute for Effexor).
poster:Tony P
thread:853657
URL: http://www.dr-bob.org/babble/20080915/msgs/853753.html