Posted by linkadge on August 12, 2008, at 16:01:25
In reply to Re: Amphetamine neurotoxicity in therapeutic doses, posted by linkadge on August 12, 2008, at 15:56:22
In defense though, I do not believe that euphoria is the mechanism of action of the amphetamines in ADHD. There are plenty of euphoriants which do not improve ADHD symptoms.
A fixed dose of amphetamine will only provide mood improvement for a short length of time (days or weeks at best), but they can be effective in ADHD for years.
I am still concerned though about the potential for neurotoxicity. There are other issues too which concern me, namely the long term cardiac side effects of stimulants and atomoxetine. Also a metabolite of methylphenidate has strong binding to 5-ht2b receptors and could pose risk to cardiac valves in a similar manner to the withdrawn dopamine agonists permax and cabergoline.
Linakdge
poster:linkadge
thread:845093
URL: http://www.dr-bob.org/babble/20080805/msgs/845723.html