Posted by yxibow on July 30, 2008, at 1:01:25
In reply to Re: AAP's comparison » yxibow, posted by Bob on July 29, 2008, at 19:13:12
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> > The response varies wildly to them as I've seen in this thread.
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> > Potency can roughly be said to be Risperdal/Invega (at a high enough dose nearly Haldol occupancy), Geodon/Abilify, and Zyprexa/Seroquel.
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> > Seroquel was finally my agent. Yes, people will note the lipid changing qualities of Zyprexa and Seroquel (and even Risperdal for that matter in some cases), but its all I have left. And this is off label. It doesn't work as well as it used to, but since they haven't invented anything as calm and free of EPS as it except for Clozaril, its about the only option I have.
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> > -- tidings
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> > Jay
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> When you refer to potency, are you talking about against psychosis, or some other effect?
Well that's one measure, but no, occupation of D2 at a standard dose is one way of measuring, increased amount of EPS (extrapyramidal symptoms) is another. At some point all APs will occupy D2 100% at a high enough dose, but its the tenacity of how they grab and let go of it. Haldol and stronger typicals have relatively extreme tenacity and don't let go as much as low potency atypicals as Seroquel. Zyprexa is a slight exception in that it does occupy D2 more, so does its cousin Clozaril -- but again, it lets go, usually, faster.
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> Do you use AAP's as an augmentation strategy for AD's, or for some other reason?
Yes and yes -- I have a rare/orphan somatiform disorder, which you can look up in previous postings in length, it is off label -- it probably does something to have Seroquel and Luvox on board at the same time, who knows.Primarily, Seroquel improves my "functionality" by reducing "confusion" (not exactly diassociation) and to whatever extent it can, it fights an unknown reason why D2 is higher than it should be, causing ordinary psychiatric vision to be exaggerated (bright lights, etc.) and some auditory stuff like scraping of spoons on soup occasionally can set me off.
Plus a whole clustermess of additional somatoform symptoms not on the list, but most of those are transitory -- obsession about thirst, etc.
poster:yxibow
thread:841617
URL: http://www.dr-bob.org/babble/20080727/msgs/842998.html