Posted by fachad on July 6, 2008, at 22:57:27
In reply to Re: Do all TCAs feel like Desipramine? » fachad, posted by SLS on July 6, 2008, at 16:47:02
Desipramine is much more potent - in theory - as a noradregenic reuptake blocker.
However, for all the other (i.e. non-target) receptors nortriptyline is much more potent.
So you can expect more sedation, weight gain, dry mouth, constipation, dizziness on standing up, etc from nortriptyline.
Nortriptyline is a much more "dirty" drug, although it is much cleaner than the parent TCA drugs (amitriptyline/Elavil is the parent for nortriptyline and imipramine/Tofranl is the parent for desipramine).
> > No, desipramine is unique. It is a VERY potent noradrenergic drug, and has the FEWEST side effects of any of the TCAs.
> >
> > So it is likely to make you fell racey, but other TCAs are more likely to give you dry mouth, drowsiness, etc.
>
> How would you compare desipramine to nortriptyline?
>
>
> - Scott
poster:fachad
thread:838229
URL: http://www.dr-bob.org/babble/20080706/msgs/838533.html