Posted by bleauberry on June 10, 2008, at 17:53:20
In reply to Re: Rocket Fuel Failed; What Magic Combo Is Next? » bleauberry, posted by Bob on June 9, 2008, at 20:16:56
I instinctively suspect wellbutrin for a couple reasons.
First of all, while all psych drugs can induce a worse depression (percentage 5% to 15%), wellbutrin anecdotally seems significantly more guilty than the others. More frequent reports of worsened depression compared to others. No way to measure it. No proof. Just what my eyes have seen. And when wellbutrin does make depression worse, it makes it tons worse. It doesn't mess around. Depression is one of the common side effects of people who take it for smoking cessation.
The other reason is that I have seen reports that while wellbutrin has some mild dopamine reuptake inhibition (it is rather weak actually), it also slows down the metabolism of dopamine and slows down the release of dopamine.
Not cool if someone's depression has a dopamine deficit involved.The other drugs in the cocktail are very strong on serotonin, norepinephrine, and gaba, which are all anti-dopamine. Any positive dopamine effects from effexor, remeron, lamictal, or wellbutrin are likely miniscule compared to the nuclear forces being generated on serotonin and norepinephrine.
Too much norepinephrine can make someone very depressed. Too much dopamine can make someone very depressed. Too much serotonin can make some very depressed. It isn't a matter of how much, but rather the balance. After all, they call it a chemical imbalance. I suspect this cocktail has thrown the balance out of whack in a worse way, leaving dopamine squashed out.
> If there were any one drug I would point a guilty finger at, it would be wellbutrin. Valium would take a close second, with trazodone right behind it.
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> Why do you suspect Welbutrin?
poster:bleauberry
thread:833832
URL: http://www.dr-bob.org/babble/20080606/msgs/834034.html