Posted by bleauberry on May 31, 2008, at 20:25:55
In reply to Mirapex vs. Seroquel for SSRI-induced anhedonia, posted by satsumas on May 30, 2008, at 13:42:55
The mechanisms are not fully understood, but either a dopamine agonist or a dopamine antagonist can improve ssri apathy. Obviously mileage varies and what works for one is different than someone else. While it makes sense from an armchair that blocking dopamine receptors would worsen apathy, it isn't that simple or understood. My prozac apathy was improved about 70% when I added 5mg zyprexa.
I agree with Link that APs should be reserved for later trials, try other things first. Since you are already into mirapex, stay with that for a month or two. But if you come to a point where you are thinking of an AP, I personally would opt for zyprexa or abilify. Seroquel is just too much of an elephant dart for many of us.
poster:bleauberry
thread:832091
URL: http://www.dr-bob.org/babble/20080528/msgs/832271.html