Posted by linkadge on May 28, 2008, at 20:04:17
In reply to Linkadge - which 2 anti-depressants??, posted by jms600 on May 28, 2008, at 9:31:55
>Linkadge,
>You said that "These two have antagonist effect >at 5-ht2a/c, 5-ht3" Which two were you referring >to; Doxapin, Elavil or Clomipramine??
Sorry, that was not clear. All three are fairly potent 5-ht2a/c and 5-ht3 antagonists.
Clomipramine is also a moderate dopamine d1/d2/d3 antagonist, which makes it like a SSRI / AP combo.
Amitriptyline is less potent a dopamine antagonist but more potent a 5-ht2a/c antagonist.
I could not find entries on doxapin's dopamine antagonism (if any).
I was a little incorrect about imipramine, it does have *some* affinity for 5-ht2a/c but according to to PDSP database, doxapin and amitryptaline are much stronger relative 5-ht antagonists.
The following were averaged from the PDSP database.Note:
***lower numbers indicate a higher affinity***
--------Doxapin-----Amitryptaline----Imipramine
5-ht----130------------30-------------11
NET----29-------------20-------------60
5-ht2a--25-------------4--------------120
5-ht2c--9--------------6--------------120
d1------no entry-------81-------------negligable
d2------no entry-------500------------500
d3------no entry-------no entry-------300So in comaprison to imipramine, amityrptaline and doxapin are somewhat relatively more potent 5-ht antagonists.
Linkadge
poster:linkadge
thread:831465
URL: http://www.dr-bob.org/babble/20080528/msgs/831760.html