Posted by SLS on May 28, 2008, at 12:04:01
In reply to Re: i just do not understand this..., posted by undopaminergic on May 28, 2008, at 11:16:40
Hi Undopaminergic.
> > I do not receive much benefit from Nardil unless I am taking nortriptyline along with it.
> >
>
> Have you made any observations regarding its effects on blood pressure and tyramine sensitivity?I understand that the tyramine reaction is supposed to be partially blunted by the inhibition of the NE transporter. I haven't performed any blinded trials to confirm this. :-)
Adding nortriptyline to Nardil potentiates the hypotension that Nardil produces. I have fainted a few times because of it. Either drug alone does not produce such an episode for me. I have not taken my blood pressure recently to test what the addition of Deplin has done.
I will say this, though. Some people (perhaps most people) with a depressive disorder display a symptom known as dysautonomia. This is why an unmedicated depressive can experience orthostatic hypotension, dry mouth, constipation, delayed gastric emptying, elevated heart rate, palpitations, and other symptoms that reflect a shifting of autonomic function towards the sympathetic and away from the parasympathetic. The fascinating thing about this phenomenon is that it tends to get worse before it gets better. It is as if one were passing through a zone of some sort. My experience is that while drifting somewhere near the zone, a worsening of the dysautonomia follows a worsening of depression, and a mitigation of these symptoms follows an improvement in depression. I find that Nardil amplifies this phenomenon.
I believe that this is the first time I have written about this phenomenon. I have observed this dysautonomia for many years in myself and have discussed it with several doctors who concur.
- Scott
poster:SLS
thread:827439
URL: http://www.dr-bob.org/babble/20080528/msgs/831645.html