Posted by undopaminergic on May 2, 2008, at 13:58:04
In reply to tricyclics with Emsam?, posted by Roslynn on May 1, 2008, at 16:11:57
Clomipramine and impipramine in combination with a MAOI (such as EMSAM) can lead to fatal serotonin syndrome. Of course, it does depend on dose. Low doses of selegiline (the active ingredient of EMSAM) have been used safely with serotonergic drugs (citalopram in particular), but moderately severe reactions have occurred in a few cases.
The other tricyclics have no serotonergic properties; they can be used with MAOIs, although it's still prudent to closely monitor cardiovascular parameters during the initial period after starting the combination.
poster:undopaminergic
thread:826639
URL: http://www.dr-bob.org/babble/20080430/msgs/826828.html