Posted by dopamine123 on March 6, 2008, at 15:37:42
In reply to Re: SULPIRIDE » bleauberry, posted by Jamal Spelling on March 4, 2008, at 17:02:56
I've also tried amisulpride in the past and found it good for motivation and interest. It mostly helps negative schizophrenic symptoms (apathy, alogia, anhedonia, emotional blunting, and avolition). Negative symptoms are also fairly common in people with depression. I would expect sulpride to do the same.
>By "dopamine autoreceptors", do you mean D1 or D2 receptors?
Only D2/D3 receptors are autoreceptors. D1 receptors only exist as postsynaptic receptors. At a low dose, amisulpride/sulpride should only block the d2/d3 autoreceptors that control the synthesis and release of dopamine. Postsynaptic d1/d2/d3/d4/d5 are not blocked and are thus activated to a greater degree.
poster:dopamine123
thread:815882
URL: http://www.dr-bob.org/babble/20080303/msgs/816593.html