Posted by Darwin on January 29, 2008, at 16:16:22
In reply to Re: Why I would not consider taking Deplin, posted by Abby Cunningham on January 29, 2008, at 13:49:26
> also see # 3.
>
> Here is the info from the drug company's web site:
>
> 1. Folic acid is a man-made product that needs to be broken down through a lengthy 4-step process. Folate that comes from your diet (e.g. green vegetables) needs to undergo a 3-step transformation. Deplin® is able to be used immediately upon absorption.
> 2. One Deplin® 7.5mg tablet is bioequivalent to taking fifty-three 1,000 mcg folic acid tablets every day.
> 3. Deplin® is unaffected by a common genetic polymorphism that compromises the breakdown of folic acid into L-methylfolate. This polymorphism is common in over half of the general population.
>Actually, this is a bit misleading. Although taking 53 1,000 mcg folic acid tablets may result in 7.5 mg of l-methylfolate (one Deplin tablet) the opposite is not true ... l-methylfolate is not converted to folic acid. So, you could take 1000 Deplin tables yet not 1 mg of folic acid would be produced. This is significant because folic acid and l-methylfolate have different effects and it could be that the increased colon cancer rates are due to folic acid and not l-methylfolate.
poster:Darwin
thread:809519
URL: http://www.dr-bob.org/babble/20080124/msgs/809584.html