Posted by brot on January 9, 2008, at 12:12:40
In reply to Amantadine ineffective for Borna Disease Virus, posted by brot on January 8, 2008, at 12:22:31
well one and a half year ago I had a full blown psychosis and it took a year for the voices to go away. prior that I was diagnosed as dydtymic, depressive, add and social phobia. depending on the doc. they all said something else. many docs tried this and that without much sucess... since my psychotic episode I am diagnosed as schizoaffective with primary negative/depressive symptoms like lack of drice, blunted emotions, litte facial expression and well just blah....
I am just asking myself why I have this symptoms. I wonder about the possible underlying causes instead of thinking I have a "dopamine dysregulation disorder"...
there is a interesting theory about schizophrenia.
"Theories of schizophrenia: a genetic-inflammatory-vascular synthesis"
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=554096The cause of shizophrenia might be "neuroinflammation" caused by infections or even some kind of overactive immune system. basically the root of all chemical abnormalities arise because the glia cells dont work the way they should, because of inflammation.
and I think I do have some neuroinflammation. Its hard to describe it, and even harder in english..
Without certain drugs I have some kind of acid like burning pain like feeling in my head... its like i can physically feel that something isnt right there. AND some drugs, for example Amitrityline or Carbamazepine wipe this feeling away within a short ammount of time. and drugs, like carbamazepine or amitriptyline do have an anti neuroinflammatory effect as a "side effect". (look at pubmed) only problem with anitriptyline is that it makes my depression worse after some time (weeks) but this specific effekt against this feeling lasts. now I take carbamazepine which basically does the same in that regard without making anything else worse. It even helps with concentration.
So I think I do have some neuroiinflammation caused by something. maybe borna virus, or something borna virus like... or whatever.
I only have the p-24 brona antibody. presence of only this antibody is somewhat related to schizophrenia, especialle negative schizophreniia.
http://www.ncbi.nlm.nih.gov/pubmed/9566266?ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumI dont have any proof. i am just guessing. I am just trying to figure out why I react in this and that way to certain drugs, while all new ads make me worse or are ineffective.
I currently take
Amisulpride 400mg
Seroquel 200mg
Carbamazepine 300mg
and recently I am giving Opipramol a try (Insidon) because I am on the and of my rope regarding ads or ad like substances(off label) ....well thats it. maybe you find something useful written here.
byebye
poster:brot
thread:805093
URL: http://www.dr-bob.org/babble/20080105/msgs/805331.html