Posted by SLS on January 8, 2008, at 16:00:40
In reply to Re: placebo response, posted by Jamal Spelling on January 8, 2008, at 14:44:20
> > We don't know how many people the drugs actually helped, just that more remitted while on them.
>
> Although sometimes, it may even be the other way around. For example, in the SJW trial that was published in JAMA in 2002, the remission rates at 8 weeks were 31.9% for placebo and 24.8% for sertraline.
>
> I have the article in front of me right now. LOL, I still giggle when reading it. The way they conclude that the study does not support the efficacy of SJW, but they say nothing about Zoloft, even though SJW and Zoloft both failed to outperform placebo.
>
> The full, original article can be accessed at
>
> http://jama.ama-assn.org/cgi/reprint/287/14/1807
Interesting...Technically, this is a "failed study". Since it has already been well established that sertraline is more effective than placebo, this comparator acts as a fail-safe to judge the validity of the trial.
- Scott
poster:SLS
thread:804126
URL: http://www.dr-bob.org/babble/20080105/msgs/805135.html