Posted by amigan on December 14, 2007, at 23:55:49
Hello.
I known that the combination of a MAOI with a potent serotonine reuptake inhibitor like all(?) SSRIs and certain TCAs like clomipramine can easily lead to a life-threatening, serotonine syndrome.
But, would it be relatively safe to combine a MAOI with a low dose of a WEAK SRI, like trazodone, nefazodone or nortriptyline?
Furthermore, some of these ADs are also blocking certain 5-HT receptors, which could be beneficial in preventing the development of a serotonine syndrome! (On the other hand, things might be more complicated with traz/nefazodone, as they are metabolized into mCPP which is a 5-HT agonist... but anyway, i refer them as an example)What do you think?
poster:amigan
thread:800899
URL: http://www.dr-bob.org/babble/20071213/msgs/800899.html