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Wellbutrin depends on its active metabolites.

Posted by Astounder on November 15, 2007, at 20:51:30

In reply to Wellbutrin XL - When to take it?, posted by AnneL on November 6, 2007, at 21:33:45

> I am going to give Wellbutrin XL 150 mg. a try.
>
> If Wellbutrin XL is a once a day pill (24 hours) does it need to be taken in the AM to prevent insomnia?
>
> Thanks in advance. :) AnneL


All of which have long (24+ hr) half-lives and accumulate heavily. After a week or two, you'll be at a steady state and it shouldn't matter when you take.


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